Arsenic methylation, GSTT1, GSTM1, GSTP1 polymorphisms, and skin lesions

Kathleen M. McCarty, Yen Ching Chen, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Yu Mei Hsueh, Li Su, Thomas Smith, Louise Ryan, David C. Christiani

研究成果: 雜誌貢獻文章同行評審

86 引文 斯高帕斯(Scopus)

摘要

Objective: We investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions and whether GSTT1, GSTP1, and GSTM1 polymorphisms modify these relationships. Methods: A case-control study of 600 cases and 600 controls that were frequency matched on age and sex was conducted in Pabna, Bangladesh, in 2001-2002. Individual well water, urine, and blood samples were collected. Water arsenic concentration was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary arsenic speciation was determined using high performance liquid chromatography hydride with generator atomic absorption spectrometry and ICP-MS. Genotyping was conducted using multiplex polymerase chain reaction and TaqMan. Results: A 10-fold increase in primary methylation ratio [monomethylarsonic acid (MMA)/(arsenite + arsenate) was associated with a 1.50-fold increased risk of skin lesions (multivariate odds ratio = 1.50; 95% confidence interval, 1.00-2.26). We observed significant interaction on the multiplicative scale between GSTT1 wildtype and secondary methylation ratio [dimethylarsinic acid/MMA; likelihood ratio test (LRT), p = 0.01]. No significant interactions were observed for GSTM1 or GSTP1 or for primary mathylation ratios. Conclusion: Our findings suggest that increasing primary methylation ratios are associated with an increase in risk of arsenic-related skin lesions. The interaction between GSTT1 wildtype and secondary methylation ratio modifies risk of skin lesions among arsenic-exposed individuals.

原文英語
頁(從 - 到)341-345
頁數5
期刊Environmental Health Perspectives
115
發行號3
DOIs
出版狀態已發佈 - 三月 2007

ASJC Scopus subject areas

  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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