Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents

Hsiu Chen Lin, Yung Kai Huang, Horng Sheng Shiue, Liang Sien Chen, Cheuk-Sing Choy, Shiau Rung Huang, Bor Cheng Han, Yu Mei Hsueh

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMAV percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p <0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.
原文英語
頁(從 - 到)60-67
頁數8
期刊Food and Chemical Toxicology
74
DOIs
出版狀態已發佈 - 十二月 1 2014

ASJC Scopus subject areas

  • 食品科學
  • 毒理學

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