Arsenic methylation capacity and developmental delay in preschool children in Taiwan

Ru-Lan Hsieh, Ya-Li Huang, Horng Sheng Shiue, Shiau Rung Huang, Ming I. Lin, Shu Chi Mu, Chi Jung Chung, Yu-Mei Hsueh

研究成果: 雜誌貢獻文章

28 引文 (Scopus)

摘要

Environmental exposure to lead or mercury can cause neurodevelopmental damage. Arsenic is another neurotoxicant that can affect intellectual function in children. This study was designed to explore the difference of arsenic methylation capacity indices between with and without developmental delay in preschool children. We also aimed to identify whether blood levels of lead or mercury modify the effect of arsenic methylation capacity indices. A cross sectional study was conducted from August 2010 to March 2012. All participants recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In all, 63 children with developmental delay and 35 children without developmental delay were recruited. Urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were measured with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Lead and mercury levels of red blood cells were measured by inductively coupled mass spectrometry. All participants underwent developmental assessments to confirm developmental delays, including evaluations of gross motor, fine motor, speech-language, cognition, social, and emotional domains. Urinary total arsenic and MMAV percentage were significantly positively associated and DMAV percentage was negatively associated with the risk of developmental delay in a dose-dependent manner after adjustment for blood lead or mercury levels and other risk factors. A multivariate regression analysis indicated that blood lead level and arsenic methylation capacity each independently contributed to the risk of developmental delay. This is the first study to show that arsenic methylation capacity is associated with developmental delay, even without obvious environmental arsenic exposure.
原文英語
頁(從 - 到)678-686
頁數9
期刊International Journal of Hygiene and Environmental Health
217
發行號6
DOIs
出版狀態已發佈 - 2014

指紋

Arsenic
Preschool Children
Taiwan
Methylation
Mercury
Environmental Exposure
Cacodylic Acid
Teaching Hospitals
Cognition
Mass Spectrometry
Spectrum Analysis
Language
Multivariate Analysis
Cross-Sectional Studies
Erythrocytes
High Pressure Liquid Chromatography
Regression Analysis
Lead

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

引用此文

Arsenic methylation capacity and developmental delay in preschool children in Taiwan. / Hsieh, Ru-Lan; Huang, Ya-Li; Shiue, Horng Sheng; Huang, Shiau Rung; Lin, Ming I.; Mu, Shu Chi; Chung, Chi Jung; Hsueh, Yu-Mei.

於: International Journal of Hygiene and Environmental Health, 卷 217, 編號 6, 2014, p. 678-686.

研究成果: 雜誌貢獻文章

Hsieh, Ru-Lan ; Huang, Ya-Li ; Shiue, Horng Sheng ; Huang, Shiau Rung ; Lin, Ming I. ; Mu, Shu Chi ; Chung, Chi Jung ; Hsueh, Yu-Mei. / Arsenic methylation capacity and developmental delay in preschool children in Taiwan. 於: International Journal of Hygiene and Environmental Health. 2014 ; 卷 217, 編號 6. 頁 678-686.
@article{7f7ef8c78b024e54ab1d85363683d838,
title = "Arsenic methylation capacity and developmental delay in preschool children in Taiwan",
abstract = "Environmental exposure to lead or mercury can cause neurodevelopmental damage. Arsenic is another neurotoxicant that can affect intellectual function in children. This study was designed to explore the difference of arsenic methylation capacity indices between with and without developmental delay in preschool children. We also aimed to identify whether blood levels of lead or mercury modify the effect of arsenic methylation capacity indices. A cross sectional study was conducted from August 2010 to March 2012. All participants recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In all, 63 children with developmental delay and 35 children without developmental delay were recruited. Urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were measured with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Lead and mercury levels of red blood cells were measured by inductively coupled mass spectrometry. All participants underwent developmental assessments to confirm developmental delays, including evaluations of gross motor, fine motor, speech-language, cognition, social, and emotional domains. Urinary total arsenic and MMAV percentage were significantly positively associated and DMAV percentage was negatively associated with the risk of developmental delay in a dose-dependent manner after adjustment for blood lead or mercury levels and other risk factors. A multivariate regression analysis indicated that blood lead level and arsenic methylation capacity each independently contributed to the risk of developmental delay. This is the first study to show that arsenic methylation capacity is associated with developmental delay, even without obvious environmental arsenic exposure.",
keywords = "Arsenic, Arsenic methylation capacity, Developmental delay, Lead, Mercury",
author = "Ru-Lan Hsieh and Ya-Li Huang and Shiue, {Horng Sheng} and Huang, {Shiau Rung} and Lin, {Ming I.} and Mu, {Shu Chi} and Chung, {Chi Jung} and Yu-Mei Hsueh",
year = "2014",
doi = "10.1016/j.ijheh.2014.02.004",
language = "English",
volume = "217",
pages = "678--686",
journal = "International Journal of Hygiene and Environmental Health",
issn = "1438-4639",
publisher = "Urban und Fischer Verlag Jena",
number = "6",

}

TY - JOUR

T1 - Arsenic methylation capacity and developmental delay in preschool children in Taiwan

AU - Hsieh, Ru-Lan

AU - Huang, Ya-Li

AU - Shiue, Horng Sheng

AU - Huang, Shiau Rung

AU - Lin, Ming I.

AU - Mu, Shu Chi

AU - Chung, Chi Jung

AU - Hsueh, Yu-Mei

PY - 2014

Y1 - 2014

N2 - Environmental exposure to lead or mercury can cause neurodevelopmental damage. Arsenic is another neurotoxicant that can affect intellectual function in children. This study was designed to explore the difference of arsenic methylation capacity indices between with and without developmental delay in preschool children. We also aimed to identify whether blood levels of lead or mercury modify the effect of arsenic methylation capacity indices. A cross sectional study was conducted from August 2010 to March 2012. All participants recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In all, 63 children with developmental delay and 35 children without developmental delay were recruited. Urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were measured with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Lead and mercury levels of red blood cells were measured by inductively coupled mass spectrometry. All participants underwent developmental assessments to confirm developmental delays, including evaluations of gross motor, fine motor, speech-language, cognition, social, and emotional domains. Urinary total arsenic and MMAV percentage were significantly positively associated and DMAV percentage was negatively associated with the risk of developmental delay in a dose-dependent manner after adjustment for blood lead or mercury levels and other risk factors. A multivariate regression analysis indicated that blood lead level and arsenic methylation capacity each independently contributed to the risk of developmental delay. This is the first study to show that arsenic methylation capacity is associated with developmental delay, even without obvious environmental arsenic exposure.

AB - Environmental exposure to lead or mercury can cause neurodevelopmental damage. Arsenic is another neurotoxicant that can affect intellectual function in children. This study was designed to explore the difference of arsenic methylation capacity indices between with and without developmental delay in preschool children. We also aimed to identify whether blood levels of lead or mercury modify the effect of arsenic methylation capacity indices. A cross sectional study was conducted from August 2010 to March 2012. All participants recruited from the Shin Kong Wu Ho-Su Memorial Teaching Hospital. In all, 63 children with developmental delay and 35 children without developmental delay were recruited. Urinary arsenic species, including arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) were measured with a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Lead and mercury levels of red blood cells were measured by inductively coupled mass spectrometry. All participants underwent developmental assessments to confirm developmental delays, including evaluations of gross motor, fine motor, speech-language, cognition, social, and emotional domains. Urinary total arsenic and MMAV percentage were significantly positively associated and DMAV percentage was negatively associated with the risk of developmental delay in a dose-dependent manner after adjustment for blood lead or mercury levels and other risk factors. A multivariate regression analysis indicated that blood lead level and arsenic methylation capacity each independently contributed to the risk of developmental delay. This is the first study to show that arsenic methylation capacity is associated with developmental delay, even without obvious environmental arsenic exposure.

KW - Arsenic

KW - Arsenic methylation capacity

KW - Developmental delay

KW - Lead

KW - Mercury

UR - http://www.scopus.com/inward/record.url?scp=84902762441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902762441&partnerID=8YFLogxK

U2 - 10.1016/j.ijheh.2014.02.004

DO - 10.1016/j.ijheh.2014.02.004

M3 - Article

VL - 217

SP - 678

EP - 686

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 6

ER -