Arsenic methylation capability and human health

Yu Mei Hsueh, Yung Kai Huang, Chi Jung Chung

研究成果: 書貢獻/報告類型章節

摘要

The metabolism of inorganic arsenic takes place through a series of reactions, including reduction and oxidative methylation reactions. Biomethylation is considered a major detoxification pathway for inorganic arsenic. However, interspecies differences exist according to the efficiency with which inorganic arsenic is metabolized and excreted in urine. Intermediate trivalent methylated arsenic species are more cytotoxic and genotoxic than inorganic compounds. The arsenic methylation profile is influenced by demographic characteristics, lifestyle, diet and genetic susceptibility. Inefficient methylation is related to the risk of cancer and noncancer disease.
原文英語
主出版物標題Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic
發行者World Scientific Publishing Co.
頁面193-212
頁數20
ISBN(電子)9789814291828
ISBN(列印)9814291811, 9789814291811
DOIs
出版狀態已發佈 - 一月 1 2011

ASJC Scopus subject areas

  • Environmental Science(all)
  • Medicine(all)

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  • 引用此

    Hsueh, Y. M., Huang, Y. K., & Chung, C. J. (2011). Arsenic methylation capability and human health. 於 Health Hazards of Arsenic Poisoning Environmental: From Epidemic to Pandemic (頁 193-212). World Scientific Publishing Co.. https://doi.org/10.1142/9789814291828_0012