摘要
Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p
原文 | 英語 |
---|---|
頁(從 - 到) | 832-837 |
頁數 | 6 |
期刊 | Biochemical and Biophysical Research Communications |
卷 | 423 |
發行號 | 4 |
DOIs | |
出版狀態 | 已發佈 - 七月 13 2012 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology