Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

Yi Chieh Li, Shin Han Tsai, Shih Ming Chen, Ya Min Chang, Tzu Chuan Huang, Yu Ping Huang, Chen Tien Chang, Jen Ai Lee

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29 引文 斯高帕斯(Scopus)

摘要

Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p
原文英語
頁(從 - 到)832-837
頁數6
期刊Biochemical and Biophysical Research Communications
423
發行號4
DOIs
出版狀態已發佈 - 七月 13 2012

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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