Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

Yi Chieh Li, Shin Han Tsai, Shih Ming Chen, Ya Min Chang, Tzu Chuan Huang, Yu Ping Huang, Chen Tien Chang, Jen Ai Lee

研究成果: 雜誌貢獻 › 文章

24 引文 (Scopus)

摘要

Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p
原文英語
頁（從 - 到）832-837
頁數6
期刊Biochemical and Biophysical Research Communications
卷423
發行號4
DOIs
出版狀態已發佈 - 七月 13 2012

指紋

Pyruvaldehyde
Aristolochia
Inbred C3H Mouse
Diabetes Complications
Medical problems
Atrophy
Renal Insufficiency
Creatinine
Fatty Acids
Aging of materials
Kidney
Glucose
aristolochic acid I
N(6)-carboxymethyllysine
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

引用此文

Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine : An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy. / Li, Yi Chieh; Tsai, Shin Han; Chen, Shih Ming; Chang, Ya Min; Huang, Tzu Chuan; Huang, Yu Ping; Chang, Chen Tien; Lee, Jen Ai.

於: Biochemical and Biophysical Research Communications, 卷 423, 編號 4, 13.07.2012, p. 832-837.

研究成果: 雜誌貢獻 › 文章

Li, YC, Tsai, SH, Chen, SM, Chang, YM, Huang, TC, Huang, YP, Chang, CT & Lee, JA 2012, 'Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy', Biochemical and Biophysical Research Communications, 卷 423, 編號 4, 頁 832-837. https://doi.org/10.1016/j.bbrc.2012.06.049
Li YC, Tsai SH, Chen SM, Chang YM, Huang TC, Huang YP 等. Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy. Biochemical and Biophysical Research Communications. 2012 7月 13;423(4):832-837. https://doi.org/10.1016/j.bbrc.2012.06.049
Li, Yi Chieh ; Tsai, Shin Han ; Chen, Shih Ming ; Chang, Ya Min ; Huang, Tzu Chuan ; Huang, Yu Ping ; Chang, Chen Tien ; Lee, Jen Ai. / Aristolochic acid-induced accumulation of methylglyoxal and N ε-(carboxymethyl)lysine : An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy. 於: Biochemical and Biophysical Research Communications. 2012 ; 卷 423, 編號 4. 頁 832-837.
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abstract = "Aristolochic acid, found in the Aristolochia species, causes aristolochic acid nephropathy (AAN) and can develop into renal failure. Methylglyoxal (MGO) is a highly cytotoxic compound generated from the metabolic process of glucose or fatty acids. It binds to proteins and forms N ε-(carboxymethyl)lysine (CML), which contributes to aging and diabetes mellitus complications. However, no relevant literature explores the relationship of MGO and CML with AAN. By injecting AA (10mg/kg BW) into C3H/He mice for 5 consecutive days, we successfully developed an AAN model and observed tubular atrophy with decreased renal function. Creatinine clearance also decreased from 10.32±0.79ml/min/kg to 2.19±0.29ml/min/kg (p",
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