Arginine methylation regulates the p53 response

Martin Jansson, Stephen T. Durant, Er Chieh Cho, Sharon Sheahan, Mariola Edelmann, Benedikt Kessler, Nicholas B. La Thangue

研究成果: 雜誌貢獻文章

272 引文 斯高帕斯(Scopus)

摘要

Activation of the p53 tumour suppressor protein in response to DNA damage leads to apoptosis or cell-cycle arrest. Enzymatic modifications are widely believed to affect and regulate p53 activity. We describe here a level of post-translational control that has an important functional consequence on the p53 response. We show that the protein arginine methyltransferase (PRMT) 5, as a co-factor in a DNA damage responsive co-activator complex that interacts with p53, is responsible for methylating p53. Arginine methylation is regulated during the p53 response and affects the target gene specificity of p53. Furthermore, PRMT5 depletion triggers p53-dependent apoptosis. Thus, methylation on arginine residues is an underlying mechanism of control during the p53 response.

原文英語
頁(從 - 到)1431-1439
頁數9
期刊Nature cell biology.
10
發行號12
DOIs
出版狀態已發佈 - 2008
對外發佈Yes

ASJC Scopus subject areas

  • Cell Biology

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  • 引用此

    Jansson, M., Durant, S. T., Cho, E. C., Sheahan, S., Edelmann, M., Kessler, B., & La Thangue, N. B. (2008). Arginine methylation regulates the p53 response. Nature cell biology., 10(12), 1431-1439. https://doi.org/10.1038/ncb1802