Locked compression plates have been widely used for the treatment of diaphyseal femoral fractures. The purpose of this study was to discover the best screw configurations in the twelve-hole bone plate by using a biomechanical optimization method namely finite element analysis-based discrete particle swarm optimization. The results showed that increasing the number of screws decreased the deflection of the constructs, and the performance of three screws per main segment showed no significant difference as compared to all screws occupying the plate holes. We concluded that stability can be achieved by increasing the number of screws and three screws on either of the segment can provide sufficient stability while minimizing the complications of plate fixation.
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