Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines

Hsueh Yun Lee, Lin Wen Lee, Chih Ying Nien, Ching Chuan Kuo, Pen Yuan Lin, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3′ of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3′-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.

原文英語
頁(從 - 到)9593-9600
頁數8
期刊Organic and Biomolecular Chemistry
10
發行號48
DOIs
出版狀態已發佈 - 2012

指紋

colchicine
Colchicine
Tubulin
Substitution reactions
substitutes
rings
products
indium(III) hydroxide

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

引用此文

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines. / Lee, Hsueh Yun; Lee, Lin Wen; Nien, Chih Ying; Kuo, Ching Chuan; Lin, Pen Yuan; Chang, Chi Yen; Chang, Jang Yang; Liou, Jing Ping.

於: Organic and Biomolecular Chemistry, 卷 10, 編號 48, 2012, p. 9593-9600.

研究成果: 雜誌貢獻文章

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abstract = "A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3′ of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3′-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.",
author = "Lee, {Hsueh Yun} and Lee, {Lin Wen} and Nien, {Chih Ying} and Kuo, {Ching Chuan} and Lin, {Pen Yuan} and Chang, {Chi Yen} and Chang, {Jang Yang} and Liou, {Jing Ping}",
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AU - Lee, Lin Wen

AU - Nien, Chih Ying

AU - Kuo, Ching Chuan

AU - Lin, Pen Yuan

AU - Chang, Chi Yen

AU - Chang, Jang Yang

AU - Liou, Jing Ping

PY - 2012

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