Application of bioaffinity technology in therapeutic extracorporeal plasmapheresis and large-scale fractionation of human plasma

T. Burnouf, H. Goubran, M. Radosevich

研究成果: 雜誌貢獻回顧型文獻

22 引文 (Scopus)

摘要

This paper describes the increasingly unique and powerful role that affinity chromatography is occupying both as a tool for the treatment of extracorporeal plasma exchange (to discard biological compounds with noxious metabolic or immunologic effects in patients) and as a purification tool in the production of therapeutic plasma protein derivatives. Management of both applications requires careful monitoring of the parameters applied to the plasma material, to avoid immunological stimulation or activation of the coagulation cascade. Examples of direct current applications of affinity ligands in therapeutic removal and industrial production of plasma compounds are presented. Copyright (C) 1998 Elsevier Science B.V.
原文英語
頁(從 - 到)65-80
頁數16
期刊Journal of Chromatography B: Biomedical Applications
715
發行號1
DOIs
出版狀態已發佈 - 九月 11 1998
對外發佈Yes

指紋

Plasma (human)
Fractionation
Plasmas
Affinity chromatography
Coagulation
Purification
Blood Proteins
Chemical activation
Ligands
Derivatives
Monitoring

ASJC Scopus subject areas

  • Chemistry(all)

引用此文

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AU - Goubran, H.

AU - Radosevich, M.

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AB - This paper describes the increasingly unique and powerful role that affinity chromatography is occupying both as a tool for the treatment of extracorporeal plasma exchange (to discard biological compounds with noxious metabolic or immunologic effects in patients) and as a purification tool in the production of therapeutic plasma protein derivatives. Management of both applications requires careful monitoring of the parameters applied to the plasma material, to avoid immunological stimulation or activation of the coagulation cascade. Examples of direct current applications of affinity ligands in therapeutic removal and industrial production of plasma compounds are presented. Copyright (C) 1998 Elsevier Science B.V.

KW - Plasma fractionation

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KW - Proteins

KW - Reviews

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