Apoptotic toxicity of destruxin B in human non-Hodgkin lymphoma cells

Pin Zhir Chao, Yi Ping Chin, I. Uen Hsu, Cheng-Ming Liu, Ya Chi Yu, Ting-Kai Leung, Yuarn Jang Lee, Chien Ho Chen, Yung Feng Lin

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Destruxins are fungal toxins used as insecticides. Recent reports demonstrated the potential anti-cancer activities of destruxin B (DB). This study is to discover the effects of DB in lymphoma. Flow cytometry and Western blotting were used to analyze apoptosis and protein expression, respectively, in Toledo human non-Hodgkin lymphoma cells in response to DB. Administration of DB, induced apoptosis via death receptor pathway activating Fas associated death domain (FADD), caspase 8 and caspase 3, and suppressed the cell growth. In addition, DB alterated mitochondrial membrane potential by increasing the expressions of tBid and Bax, but decreasing the levels of Bcl-2, resulting in the release of apoptosis-inducing factor (AIF). In conclusion, apoptosis of human non-Hodgkin lymphoma cells in response to DB is induced through the death receptor pathway and involves an alteration of the mitochondrial membrane potential. These findings may aid the development of novel treatment of non-Hodgkin lymphoma.
原文英語
頁(從 - 到)1870-1876
頁數7
期刊Toxicology in Vitro
27
發行號6
DOIs
出版狀態已發佈 - 九月 2013

ASJC Scopus subject areas

  • Toxicology

指紋 深入研究「Apoptotic toxicity of destruxin B in human non-Hodgkin lymphoma cells」主題。共同形成了獨特的指紋。

  • 引用此