Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

H. J. Harn; H. F. Hsieh; L. I. Ho; C. P. Yu; J. H. Chen; C. C. Chiu; H. C. Fan; W. H. Lee

doi:10.1046/j.1365-2559.1998.00470.x

Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

H. J. Harn, H. F. Hsieh, L. I. Ho, C. P. Yu, J. H. Chen, C. C. Chiu, H. C. Fan, W. H. Lee

研究成果: 雜誌貢獻 › 文章 › 同行評審

18 引文斯高帕斯（Scopus）

摘要

Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P

原文	英語
頁（從 - 到）	117-122
頁數	6
期刊	Histopathology
卷	33
發行號	2
DOIs	https://doi.org/10.1046/j.1365-2559.1998.00470.x
出版狀態	已發佈 - 1998
對外發佈	是

ASJC Scopus subject areas

解剖學
病理學與法醫學
細胞生物學

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10.1046/j.1365-2559.1998.00470.x

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abstract = "Aims: We investigated the significance of apoptosis, using the terminal deoxynucleotidyl transferase mediated dUTP-digoxigenin nick end-labelling method, in nasopharyngeal carcinoma biopsy samples. Methods and results: The apoptotic index (AI) in 50 nasopharyngeal carcinomas was compared with various histopathological features and clinical stage. Also, the AI was correlated with p53, bcl-2 and Ki67 expression by immunohistochemistry. In histopathological studies, the AI was significantly higher in mixed cellular type (MC) than in keratizing squamous cell type (KS) and spindle cell type (SC) (P",

keywords = "Apoptosis, bcl-2, Ki67, Nasopharyngeal carcinoma, p53",

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AU - Harn, H. J.

AU - Hsieh, H. F.

AU - Ho, L. I.

AU - Yu, C. P.

AU - Chen, J. H.

AU - Chiu, C. C.

AU - Fan, H. C.

AU - Lee, W. H.

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Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage

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ASJC Scopus subject areas

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