APCcdh1 Activity in Mouse Oocytes Prevents Entry into the First Meiotic Division

Alexandra Reis, Heng Yu Chang, Mark Levasseur, Keith T. Jones

研究成果: 雜誌貢獻文章同行評審

120 引文 斯高帕斯(Scopus)

摘要

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.

原文英語
頁(從 - 到)539-540
頁數2
期刊Nature Cell Biology
8
發行號5
DOIs
出版狀態已發佈 - 五月 2006
對外發佈

ASJC Scopus subject areas

  • 細胞生物學

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