Apamin modulates electrophysiological characteristics of the pulmonary vein and the Sinoatrial Node

Wei Ta Chen, Yao Chang Chen, Yen Yu Lu, Yu Hsun Kao, Jen Hung Huang, Yung Kuo Lin, Shih Ann Chen, Yi Jen Chen

研究成果: 雜誌貢獻文章

20 引文 斯高帕斯(Scopus)

摘要

Background: Small-conductance calcium-activated potassium (SK) channels play an important role in atrial electrophysiology. Blocking SK channels prolongs action potential (AP) duration and attenuate electrical remodelling. The effects of SK blocking on the pulmonary vein (PV) and the sinoatrial node (SAN) remain unclear. Materials and methods: Conventional microelectrodes were used to record the AP in SANs and in isolated rabbit PVs with and without denudation before and after treatment with apamin (1, 10 nM). Using the whole-cell patch-clamp technique, the SK current was investigated in isolated single PV and SAN myocytes. Results: In nondenudated PVs (n = 6), apamin (1 and 10 nM) increased PV spontaneous activity (from 1·8 ± 0·2 Hz to 2·4 ± 0·2 Hz and 2·3 ± 0·2 Hz, P 

原文英語
頁(從 - 到)957-963
頁數7
期刊European Journal of Clinical Investigation
43
發行號9
DOIs
出版狀態已發佈 - 九月 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Biochemistry
  • Biochemistry

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