Antitussive effects of azepino[2,1-b]quinazolones

Kunal Nepali, Mukunda S. Bande, Sameer Sapra, Atul Garg, Sunil Kumar, Punita Sharma, Rohit Goyal, Naresh Kumar Satti, Om Parkash Suri, Kanaya Lal Dhar

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

A series of azepino[2,1-b]quinazolones (C-1-C-16) have been synthesized and evaluated for their antitussive activity using citric acid-induced cough model in Guinea pigs. The compounds C-1-C-16 caused notable decrease in cough frequency and increase in cough latency induced by citric acid. C-3 [2,4-dibromo-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one] showed notable antitussive effect as compared with codeine (10 mg/kg). Various substitutions were made at Rings A and B, and all substituents like methoxy, hydroxyl, nitro, amino (Ring A) and alkyl, acetyl, benzoyl (Ring B) other than bromine were found to reduce the potential of the unsubstituted 7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one as antitussive.
原文英語
頁(從 - 到)1271-1277
頁數7
期刊Medicinal Chemistry Research
21
發行號7
DOIs
出版狀態已發佈 - 七月 1 2012
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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