Antitumor effects of osthol from Cnidium monnieri: An in vitro and in vivo study

Szu-Yuan Chou, Chun-Sen Hsu, Kun Teng Wang, Min Chieh Wang, Ching Chiung Wang

研究成果: 雜誌貢獻文章同行評審

105 引文 斯高帕斯(Scopus)

摘要

Cnidium monnieri (L.) Cusson is a Chinese medicine which is used widely by traditional medicine doctors. Osthol is a major bio-activity compound of the herb. In this study, osthol was isolated from C. monnieri and its in vitro and in vivo antitumor effects studied. The results of the in vitro study showed: that osthol inhibited the growth of HeLa, in a time- and concentration-dependent manner, with IC50, values of 77.96 and 64.94 μM for 24 and 48 h, respectively; that osthol had lower cytotoxic effects in primary cultured normal cervical fibroblasts; and that increased DNA fragmentation and activated PARP in HeLa after treatment with osthol which could induce apoptosis. The results of the in vivo model showed that the survival days of the P-388 D1 tumor-bearing CDF, mice were prolonged (ILS% = 37) after osthol (30 mg/kg) was given once a day for 9 days. Based on these results, it is suggested that osthol could inhibit P-388 D1 cells in vivo and induce apoptosis in HeLa cells in vitro, and that osthol is good lead compound for developing antitumor drugs. However, C. formosanum Yabe of Taiwan's endemic plants contained little osthol, with no imperatorin, and its major components were different from that of C. monnieri. Therefore, it is suggested that C. formosanum also may possess economic worth.
原文英語
頁(從 - 到)226-230
頁數5
期刊Phytotherapy Research
21
發行號3
DOIs
出版狀態已發佈 - 三月 2007

ASJC Scopus subject areas

  • 有機化學
  • 藥物發現
  • 藥理

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