Antipsychotics and the Risk of Cerebrovascular Accident: A Systematic Review and Meta-Analysis of Observational Studies

Wan Ting Hsu, Amin Esmaily-Fard, Chih Cheng Lai, Darshan Zala, Sie Huei Lee, Shy Shin Chang, Chien Chang Lee

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

Background Studies investigating the association between antipsychotic use and the risk of cerebrovascular accident (CVA) showed inconsistent results. Aim Conduct a systematic review and meta-analysis to evaluate whether use of antipsychotics is associated with increased risk of CVA. Methods Major electronic databases were searched from 1970 to October 2016 for observational studies investigating the risk of CVA among users of antipsychotics. Pooled estimates of odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by random effects meta-analysis. Results Of 1171 citations identified, 10 studies were considered eligible. Significant increase in risk of CVA was associated with first-generation antipsychotics (OR 1.49; 95% CI 1.24–1.77) but not with second-generation antipsychotics (OR 1.31; 95% CI 0.74–2.30). Use of any antipsychotics in patients with dementia was associated with a low risk of CVA (OR 1.17; 95% CI 1.08–1.26). Conclusions The available evidence suggests use of with first-generation antipsychotics as opposed to second-generation antipsychotics significantly increased the risk of CVA.

原文英語
頁(從 - 到)692-699
頁數8
期刊Journal of the American Medical Directors Association
18
發行號8
DOIs
出版狀態已發佈 - 八月 1 2017
對外發佈

ASJC Scopus subject areas

  • 護理(全部)
  • 健康政策

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