Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen; Chien Chih Chiu; Rou Wen Haung; Chi Chen Yeh; Kuang Jing Huang; Kuo Feng Chang; You Cheng Hseu; Fang Rong Chang; Hsueh Wei Chang; Yang Chang Wu

doi:10.1016/j.mrgentox.2012.06.003

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen, Chien Chih Chiu, Rou Wen Haung, Chi Chen Yeh, Kuang Jing Huang, Kuo Feng Chang, You Cheng Hseu, Fang Rong Chang, Hsueh Wei Chang, Yang Chang Wu

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64 引文斯高帕斯（Scopus）

摘要

Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

原文	英語
頁（從 - 到）	253-258
頁數	6
期刊	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
卷	747
發行號	2
DOIs	https://doi.org/10.1016/j.mrgentox.2012.06.003
出版狀態	已發佈 - 9月 18 2012

ASJC Scopus subject areas

健康、毒理學和誘變
遺傳學

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/j.mrgentox.2012.06.003

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引用此

Yen, C. Y., Chiu, C. C., Haung, R. W., Yeh, C. C., Huang, K. J., Chang, K. F., Hseu, Y. C., Chang, F. R., Chang, H. W., & Wu, Y. C. (2012). Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 747(2), 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

Yen, CY, Chiu, CC, Haung, RW, Yeh, CC, Huang, KJ, Chang, KF, Hseu, YC, Chang, FR, Chang, HW & Wu, YC 2012, 'Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction', Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 卷 747, 編號 2, 頁 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

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abstract = "Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p",

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author = "Yen, {Ching Yu} and Chiu, {Chien Chih} and Haung, {Rou Wen} and Yeh, {Chi Chen} and Huang, {Kuang Jing} and Chang, {Kuo Feng} and Hseu, {You Cheng} and Chang, {Fang Rong} and Chang, {Hsueh Wei} and Wu, {Yang Chang}",

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AU - Yen, Ching Yu

AU - Chiu, Chien Chih

AU - Haung, Rou Wen

AU - Yeh, Chi Chen

AU - Huang, Kuang Jing

AU - Chang, Kuo Feng

AU - Hseu, You Cheng

AU - Chang, Fang Rong

AU - Chang, Hsueh Wei

AU - Wu, Yang Chang

PY - 2012/9/18

Y1 - 2012/9/18

N2 - Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

AB - Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

KW - γH2AX

KW - Apoptosis

KW - Goniothalamin

KW - Mitochondrial membrane potential

KW - Oral cancer

KW - ROS

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Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

摘要

ASJC Scopus subject areas

UN SDG

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