摘要
Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p
原文 | 英語 |
---|---|
頁(從 - 到) | 253-258 |
頁數 | 6 |
期刊 | Mutation Research - Genetic Toxicology and Environmental Mutagenesis |
卷 | 747 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 9月 18 2012 |
ASJC Scopus subject areas
- 健康、毒理學和誘變
- 遺傳學