Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen, Chien Chih Chiu, Rou Wen Haung, Chi Chen Yeh, Kuang Jing Huang, Kuo Feng Chang, You Cheng Hseu, Fang Rong Chang, Hsueh Wei Chang, Yang Chang Wu

研究成果: 雜誌貢獻文章同行評審

61 引文 斯高帕斯(Scopus)

摘要

Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p
原文英語
頁(從 - 到)253-258
頁數6
期刊Mutation Research - Genetic Toxicology and Environmental Mutagenesis
747
發行號2
DOIs
出版狀態已發佈 - 九月 18 2012

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

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