Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen; Chien Chih Chiu; Rou Wen Haung; Chi Chen Yeh; Kuang Jing Huang; Kuo Feng Chang; You Cheng Hseu; Fang Rong Chang; Hsueh Wei Chang; Yang Chang Wu

doi:10.1016/j.mrgentox.2012.06.003

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen, Chien Chih Chiu, Rou Wen Haung, Chi Chen Yeh, Kuang Jing Huang, Kuo Feng Chang, You Cheng Hseu, Fang Rong Chang, Hsueh Wei Chang, Yang Chang Wu

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研究成果: 雜誌貢獻 › 文章 › 同行評審

61 引文斯高帕斯（Scopus）

摘要

Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

原文	英語
頁（從 - 到）	253-258
頁數	6
期刊	Mutation Research - Genetic Toxicology and Environmental Mutagenesis
卷	747
發行號	2
DOIs	https://doi.org/10.1016/j.mrgentox.2012.06.003
出版狀態	已發佈 - 九月 18 2012

ASJC Scopus subject areas

Health, Toxicology and Mutagenesis
Genetics

UN SDG

此研究成果有助於以下永續發展目標

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10.1016/j.mrgentox.2012.06.003

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引用此

Yen, C. Y., Chiu, C. C., Haung, R. W., Yeh, C. C., Huang, K. J., Chang, K. F., Hseu, Y. C., Chang, F. R., Chang, H. W., & Wu, Y. C. (2012). Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 747(2), 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. / Yen, Ching Yu; Chiu, Chien Chih; Haung, Rou Wen; Yeh, Chi Chen; Huang, Kuang Jing; Chang, Kuo Feng; Hseu, You Cheng; Chang, Fang Rong; Chang, Hsueh Wei; Wu, Yang Chang.

於: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 卷 747, 編號 2, 18.09.2012, p. 253-258.

研究成果: 雜誌貢獻 › 文章 › 同行評審

Yen, CY, Chiu, CC, Haung, RW, Yeh, CC, Huang, KJ, Chang, KF, Hseu, YC, Chang, FR, Chang, HW & Wu, YC 2012, 'Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction', Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 卷 747, 編號 2, 頁 253-258. https://doi.org/10.1016/j.mrgentox.2012.06.003

Yen, Ching Yu ; Chiu, Chien Chih ; Haung, Rou Wen ; Yeh, Chi Chen ; Huang, Kuang Jing ; Chang, Kuo Feng ; Hseu, You Cheng ; Chang, Fang Rong ; Chang, Hsueh Wei ; Wu, Yang Chang. / Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction. 於: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2012 ; 卷 747, 編號 2. 頁 253-258.

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abstract = "Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p",

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AU - Haung, Rou Wen

AU - Yeh, Chi Chen

AU - Huang, Kuang Jing

AU - Chang, Kuo Feng

AU - Hseu, You Cheng

AU - Chang, Fang Rong

AU - Chang, Hsueh Wei

AU - Wu, Yang Chang

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AB - Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

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KW - Mitochondrial membrane potential

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