Antioxidative natural product protect against econazole-induced liver injuries

Chi Feng Liu, Chia Hsien Lin, Chun Ching Lin, Yun Ho Lin, Chin Fa Chen, Chao Kuang Lin, Song-Chow Lin

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

The study objective of this research is in order to investigate the hepatoprotective and therapeutic effects of propolis ethanol extract (PEE) on acute econazole-induced liver injury. Positive control of various concentrations of PEE on liver function and the dose-response relationship of liver injury induced by various doses of econazole were firstly observed from biochemical assay of serum level of aspartate transaminase (SGOT) and serum alanine transaminase (SGPT) and histopathological microscopic examination. The hepatoprotective effects of various concentration of PEE on liver damage induced by hepatotoxic dose (300mg/kg) of econazole were observed by the obvious decrement of SGOT and SGPT level and further confirmed by hepatohistological microscopic examination. The inhibitory effects of PEE on FeCl2-induced (in vitro) or econazole-induced (in vivo) lipid peroxidation were investigated from the measurement of the formed malonic dialdehyde (MDA) level in the rat liver homogenate. The IC50 (μM) of various concentrations of PEE in the superoxide scavenging activity in econazole (300mg/kg)-damaged rat liver homogenate were assessed by cytochrome c reduction method and compared with that of (+)-alpha-tocopherol. It could be postulated that the hepatoprotective effect of PEE may be, at least in part, due to their inhibitory ability on membrane lipid peroxidation and free radical formation or due to their free radical scavenging ability.
原文英語
頁(從 - 到)87-93
頁數7
期刊Toxicology
196
發行號1-2
DOIs
出版狀態已發佈 - 三月 1 2004

ASJC Scopus subject areas

  • Toxicology

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    Liu, C. F., Lin, C. H., Lin, C. C., Lin, Y. H., Chen, C. F., Lin, C. K., & Lin, S-C. (2004). Antioxidative natural product protect against econazole-induced liver injuries. Toxicology, 196(1-2), 87-93. https://doi.org/10.1016/j.tox.2003.11.007