Antioxidant Effects of Chromium Supplementation with Type 2 Diabetes Mellitus and Euglycemic Subjects

Hsing-Hsien Cheng, Ming Hoang Lai, Wen C. Hou, Chen-Ling Huang

研究成果: 雜誌貢獻文章

48 引文 斯高帕斯(Scopus)

摘要

To determine the effects of chromium (Cr) supplementations on oxidative stress of type 2 diabetes and euglycemic (EU) subjects, adult having HbA 1c values of 8.5% (severely hyperglycemic, SH) were supplemented for 6 months with 1000 μg/day of Cr (as Cr yeast) or with a placebo. In the beginning, the levels of the plasma Cr in the MH and SH groups were 25-30% lower than those of the EU subjects. The values of thiobarbituric acid reactive substances (TBARS) and total antioxidative status (TAS) of the MH and SH groups were significantly higher than those of the EU ones. Following supplementations, the levels of plasma TBARS in the Cr groups of MH and SH groups were significantly decreased (the inverse was found in the EU) and showed no significant changes in the placebo group. The levels of plasma TAS in the Cr groups of EU and MH were significantly decreased (the inverse was found in the SH) and showed no significant changes in the placebo group. No significant difference was found in the antioxidant enzyme (superoxide dismutase, glutathione peroxidase, catalase) activities during supplementations. These data suggest that Cr supplementation was an effective treatment strategy to minimize increased oxidative stress in type 2 diabetes mellitus patients whose HbA1c level was >8.5%, and the Cr in EU groups might act as a prooxidant.
原文英語
頁(從 - 到)1385-1389
頁數5
期刊Journal of Agricultural and Food Chemistry
52
發行號5
出版狀態已發佈 - 三月 10 2004

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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