Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Chi Han Wu, Chun Hsu Pan, Ching Kuo Lee, Ming Jyh Sheu, Fon Chang Liu, Guei Jane Wang, Chieh Hsi Wu

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.

原文英語
頁(從 - 到)173-182
頁數10
期刊Journal of Functional Foods
24
DOIs
出版狀態已發佈 - 六月 1 2016

指紋

Hypolipidemic Agents
atherogenesis
hyperlipidemia
Hyperlipidemias
Atherosclerosis
obesity
Obesity
adjuvants
animals
CCAAT-Enhancer-Binding Proteins
Hydroxymethylglutaryl CoA Reductases
Acetyl-CoA Carboxylase
AMP-activated protein kinase
acetyl-CoA carboxylase
Peroxisome Proliferator-Activated Receptors
adiponectin
PPAR gamma
Adiponectin
natural foods
fatty liver

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

引用此文

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans. / Wu, Chi Han; Pan, Chun Hsu; Lee, Ching Kuo; Sheu, Ming Jyh; Liu, Fon Chang; Wang, Guei Jane; Wu, Chieh Hsi.

於: Journal of Functional Foods, 卷 24, 01.06.2016, p. 173-182.

研究成果: 雜誌貢獻文章

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abstract = "Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.",
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