Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus

Ju Fang Wu, Yao Hsu Yang, Li Chieh Wang, Jyh Hong Lee, Ein Yiao Shen, Bor Luen Chiang

研究成果: 雜誌貢獻文章同行評審

22 引文 斯高帕斯(Scopus)

摘要

We compared the serum levels of antinucleosome antibodies (anti-NCS Abs) in thirty pediatric systemic lupus erythematosus (SLE) patients by using enzyme-linked immunosorbent assay (ELISA) to 29 adult SLE patients, 30 healthy controls, 21 juvenile idiopathic arthritis (JIA) and 23 Henoch-Schonlein purpura (HSP) patients as autoimmune disease controls. The mean anti-NCS Ab titer in the pediatric SLE patients was 1552.7 ± 1842.2 U/ml, higher than those of adult SLE patients (194.3 ± 402.7 U/ml), normal controls (9.5 ± 5.7 U/ml) and disease controls (JIA: 7.7 ± 4.0 U/ml, HSP: 5.7 ± 4.4 U/ml) (p <0.05). The prevalence of both anti-NCS Ab (90%) and anti-ds DNA Ab (76.7%) in pediatric SLE patients were higher (p <0.05) than that of adult SLE patients (58.6% and 48.3%). A positive correlation was demonstrated between anti-NCS Ab and anti-dsDNA Ab as well as the SLEDAI scores in pediatric and adult patients (p <0.05). The inverse correlation of anti-NCS Ab levels with C3 was observed in both pediatric and adult SLE patients (pediatrics, r = - 0.61, p = 0.0003; adult, r = - 0.44, p = 0.02). Our data suggested that in pediatric SLE patients, anti-NCS Ab could be as good a marker for SLE diagnosis and disease activity assessment as in adult SLE patients.
原文英語
頁(從 - 到)119-124
頁數6
期刊Journal of Autoimmunity
27
發行號2
DOIs
出版狀態已發佈 - 九月 2006

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學

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