Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Ronni L. Weinkauf, Allan Y. Chen, Chiang Yu, Leroy-Fong Liu, Louis Barrows, Edmond J. LaVoie

研究成果: 雜誌貢獻文章同行評審

44 引文 斯高帕斯(Scopus)

摘要

Substituted pyrido[3,4-b]carbazoles, pyrido[2,3-b]carbazoles, indolo[2,3-b]quinolines, and benzimidazo[1,2-b]-isoquinolines were synthesized and evaluated for biological activity. Several methylated derivatives of these heterocyclic compounds had similar activity to ellipticine as mammalian topoisomerase II inhibitors. Methylated derivatives of these heterocyclic compounds were also highly active in vitro, inhibiting the growth of several human tumor cell lines. These data demonstrate that the antineoplastic activity associated with ellipticine can be retained within a wide variety of analogous heterocyclics.

原文英語
頁(從 - 到)781-786
頁數6
期刊Bioorganic and Medicinal Chemistry
2
發行號8
DOIs
出版狀態已發佈 - 1994
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 有機化學
  • 藥物發現
  • 藥學科學

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