Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

Ju Chi Liu, Feng-Lin Hsu, Jen Chen Tsai, Paul Chan, Jenny Ya Hsin Liu, G. Neil Thomas, Brian Tomlinson, Ming Yu Lo, Jung Yaw Lin

研究成果: 雜誌貢獻文章同行評審

100 引文 斯高帕斯(Scopus)

摘要

The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC 50), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC 50
原文英語
頁(從 - 到)1543-1555
頁數13
期刊Life Sciences
73
發行號12
DOIs
出版狀態已發佈 - 八月 8 2003

ASJC Scopus subject areas

  • Pharmacology

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