摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1-6 |
| 頁數 | 6 |
| 期刊 | Chinese Medical Journal (Taipei) |
| 卷 | 65 |
| 發行號 | 1 |
| 出版狀態 | 已發佈 - 2002 |
指紋
ASJC Scopus subject areas
- Medicine(all)
引用此文
Antihypertensive effect of stevioside in different strains of hypertensive rats. / Hsu, Yung Ho; Liu, Ju Chi; Kao, Pai Feng; Lee, Chun-Nin; Chen, Yi Jen; Hsieh, Ming Hsiung; Chan, Paul.
於: Chinese Medical Journal (Taipei), 卷 65, 編號 1, 2002, p. 1-6.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Antihypertensive effect of stevioside in different strains of hypertensive rats
AU - Hsu, Yung Ho
AU - Liu, Ju Chi
AU - Kao, Pai Feng
AU - Lee, Chun-Nin
AU - Chen, Yi Jen
AU - Hsieh, Ming Hsiung
AU - Chan, Paul
PY - 2002
Y1 - 2002
N2 - Background. Stevioside is a natural sweet-tasting glycoside isolated from the herb Stevia rebaudiana, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used commercially as sugar substitute. Previous study has shown that it can lower blood pressure in anesthetized spontaneously hypertensive rats (SHR). This study was undertaken to evaluate the antihypertensive effect of stevioside in different strains of hypertensive rats and to observe whether there is difference in blood pressure lowering effect. Methods. Noninvasive tail-cuff method was employed to measure blood pressure. Stevioside at the concentrations of 50, 100 and 200 mg/kg were administered intraperitoneally (ip) to normotensive Wistar-Kyoto rats (NTR), SHR, deoxycorticosterone acetate-salt (DOCA-NaC1) sensitive hypertensive rats (DHR) and renal hypertensive rats (RHR). Results. Significant hypotensive effect of stevioside administered ip was noted in different strains of rats at the dose of 50 mg/kg. When stevioside was increased to the concentrations of 100 and 200 mg/kg, ip, it also caused slow and persistent lowering of blood pressure in SHR and NTR. Data also showed that stevioside given at the concentrations of 100, 200 and 400 mg/kg ip resulted in lowering of blood pressure in SHR dose-dependently. Blood pressure returned to previous levels after the drug was discontinued for 2-3 days. Drinking of 0.1% stevioside solution in mature SHR could have antihypertensive effect and also prevented hypertension in immature SHR. Conclusions. This study reconfirmed stevioside has hypotensive effect and the effect is more prominent in hypertensive rats.
AB - Background. Stevioside is a natural sweet-tasting glycoside isolated from the herb Stevia rebaudiana, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used commercially as sugar substitute. Previous study has shown that it can lower blood pressure in anesthetized spontaneously hypertensive rats (SHR). This study was undertaken to evaluate the antihypertensive effect of stevioside in different strains of hypertensive rats and to observe whether there is difference in blood pressure lowering effect. Methods. Noninvasive tail-cuff method was employed to measure blood pressure. Stevioside at the concentrations of 50, 100 and 200 mg/kg were administered intraperitoneally (ip) to normotensive Wistar-Kyoto rats (NTR), SHR, deoxycorticosterone acetate-salt (DOCA-NaC1) sensitive hypertensive rats (DHR) and renal hypertensive rats (RHR). Results. Significant hypotensive effect of stevioside administered ip was noted in different strains of rats at the dose of 50 mg/kg. When stevioside was increased to the concentrations of 100 and 200 mg/kg, ip, it also caused slow and persistent lowering of blood pressure in SHR and NTR. Data also showed that stevioside given at the concentrations of 100, 200 and 400 mg/kg ip resulted in lowering of blood pressure in SHR dose-dependently. Blood pressure returned to previous levels after the drug was discontinued for 2-3 days. Drinking of 0.1% stevioside solution in mature SHR could have antihypertensive effect and also prevented hypertension in immature SHR. Conclusions. This study reconfirmed stevioside has hypotensive effect and the effect is more prominent in hypertensive rats.
KW - Hypertension
KW - Rats
KW - Stevioside
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M3 - Article
C2 - 11939668
AN - SCOPUS:0036091433
VL - 65
SP - 1
EP - 6
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
SN - 1726-4901
IS - 1
ER -