Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora

Feng Lin Hsu, Chih Wei Lai, Juei Tang Cheng

研究成果: 雜誌貢獻文章同行評審

143 引文 斯高帕斯(Scopus)

摘要

Paeoniflorin and 8-debenzoylpaeoniflorin were isolated from the dried root of Paeonia lactiflora Pall. (Ranunculaceae). They produced a significant blood sugar lowering effect in streptozotocin-treated rats and had a maximum effect at 25 min after treatment. This hypoglycemic action was also observed in normoglycemic rats only at 1 mg/kg. The antihyperglycemic activity of 8-debenzoylpaeoniflorin seems lower than that of paeoniflorin. Plasma insulin was not changed in paeoniflorin-treated normoglycemic rats indicating an insulin-independent action. Also, this glucoside reduced the elevation of blood sugar in glucose challenged rats. Increase of glucose utilization by paeoniflorin can thus be considered. There are no previous data showing the hypoglycemic activity of paeoniflorin and/or 8-debenzoylpaeoniflorin in rats.
原文英語
頁(從 - 到)323-325
頁數3
期刊Planta Medica
63
發行號4
DOIs
出版狀態已發佈 - 1997

ASJC Scopus subject areas

  • 植物科學
  • 藥物發現
  • 有機化學
  • 藥理

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