Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats

Wei Jan Huang, Ho Shan Niu, Mei Hsiang Lin, Juei Tang Cheng, Feng-Lin Hsu

研究成果: 雜誌貢獻文章同行評審

55 引文 斯高帕斯(Scopus)

摘要

The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase glycogen synthesis in STZ-diabetic rats. These results suggest that 1 can increase glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
原文英語
頁(從 - 到)1170-1172
頁數3
期刊Journal of Natural Products
73
發行號6
DOIs
出版狀態已發佈 - 六月 25 2010

ASJC Scopus subject areas

  • 補充和替代醫學
  • 分子醫學
  • 有機化學
  • 分析化學
  • 藥學科學
  • 藥理
  • 藥物發現

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