Antihyperglycemic action of sinapic acid in diabetic rats

Yih-Giun Cherng, Cheng Chia Tsai, Hsien Hui Chung, Yun Wen Lai, Shu Chun Kuo, Juei Tang Cheng

研究成果: 雜誌貢獻文章

24 引文 (Scopus)

摘要

Sinapic acid is a hydroxycinnamic acid contained in plants. In an attempt to know the hyperglycemic effect of sinapic acid, this study applied streptozotocin (STZ) to induce type 1-like diabetic rats and fed fructose-rich chow to induce type 2-like diabetic rats. Sinapic acid dose-dependently reduced the hyperglycemia of STZ-diabetic rats (9.8 ± 1.8%, 11.6 ± 0.7%, and 19.4 ± 3.2% at 5 mg/kg, 10 mg/kg, and 25 mg/kg, respectively). Also, sinapic acid attenuated the postprandial plasma glucose without changing plasma insulin in rats. Repeated treatment of sinapic acid increased the gene expression of GLUT4 in soleus muscle of STZ-diabetic rats. Moreover, sinapic acid enhanced glucose uptake into isolated soleus muscle and L6 cells (337.0 ± 29.6%). Inhibition of phospholipase C (PLC) using U73122 (1.00 ± 0.02 μg/mg protein) or protein kinase C (PKC) using chelerythrine (0.97 ± 0.02 μg/mg protein) attenuated the sinapic acid-stimulated glucose uptake (1.63 ± 0.02 μg/mg protein) in L6 cells. Otherwise, the reduced glucose infusion rate (GIR) in fructose-rich chow-fed rats was also raised by sinapic acid. Our results suggest that sinapic acid ameliorates hyperglycemia through PLC-PKC signals to enhance the glucose utilization in diabetic rats.

原文英語
頁(從 - 到)12053-12059
頁數7
期刊Journal of Agricultural and Food Chemistry
61
發行號49
DOIs
出版狀態已發佈 - 十二月 11 2013

指紋

hypoglycemic agents
sinapic acid
Hypoglycemic Agents
Rats
rats
streptozotocin
Glucose
Streptozocin
glucose
phospholipase C
protein kinase C
Type C Phospholipases
hyperglycemia
Fructose
Hyperglycemia
Protein Kinase C
Muscle
fructose
Skeletal Muscle
uptake mechanisms

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

引用此文

Cherng, Y-G., Tsai, C. C., Chung, H. H., Lai, Y. W., Kuo, S. C., & Cheng, J. T. (2013). Antihyperglycemic action of sinapic acid in diabetic rats. Journal of Agricultural and Food Chemistry, 61(49), 12053-12059. https://doi.org/10.1021/jf403092b

Antihyperglycemic action of sinapic acid in diabetic rats. / Cherng, Yih-Giun; Tsai, Cheng Chia; Chung, Hsien Hui; Lai, Yun Wen; Kuo, Shu Chun; Cheng, Juei Tang.

於: Journal of Agricultural and Food Chemistry, 卷 61, 編號 49, 11.12.2013, p. 12053-12059.

研究成果: 雜誌貢獻文章

Cherng, Y-G, Tsai, CC, Chung, HH, Lai, YW, Kuo, SC & Cheng, JT 2013, 'Antihyperglycemic action of sinapic acid in diabetic rats', Journal of Agricultural and Food Chemistry, 卷 61, 編號 49, 頁 12053-12059. https://doi.org/10.1021/jf403092b
Cherng, Yih-Giun ; Tsai, Cheng Chia ; Chung, Hsien Hui ; Lai, Yun Wen ; Kuo, Shu Chun ; Cheng, Juei Tang. / Antihyperglycemic action of sinapic acid in diabetic rats. 於: Journal of Agricultural and Food Chemistry. 2013 ; 卷 61, 編號 49. 頁 12053-12059.
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