摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 307-312 |
| 頁數 | 6 |
| 期刊 | Journal of Oral Pathology and Medicine |
| 卷 | 46 |
| 發行號 | 4 |
| DOIs | |
| 出版狀態 | 已發佈 - 四月 1 2017 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Oral Surgery
- Otorhinolaryngology
- Cancer Research
- Periodontics
引用此文
Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. / Chang, Julia Yu Fong; Chiang, Chun Pin; Wang, Yi Ping; Wu, Yang Che; Chen, Hsin Ming; Sun, Andy.
於: Journal of Oral Pathology and Medicine, 卷 46, 編號 4, 01.04.2017, p. 307-312.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis
AU - Chang, Julia Yu Fong
AU - Chiang, Chun Pin
AU - Wang, Yi Ping
AU - Wu, Yang Che
AU - Chen, Hsin Ming
AU - Sun, Andy
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.
AB - Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.
KW - antigastric parietal cell antibody
KW - antithyroglobulin antibody
KW - antithyroid microsomal antibody
KW - desquamative gingivitis
KW - erosive oral lichen planus
UR - http://www.scopus.com/inward/record.url?scp=84992560099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992560099&partnerID=8YFLogxK
U2 - 10.1111/jop.12490
DO - 10.1111/jop.12490
M3 - Article
C2 - 27599778
AN - SCOPUS:84992560099
VL - 46
SP - 307
EP - 312
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
SN - 0904-2512
IS - 4
ER -