Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis

Julia Yu Fong Chang, Chun Pin Chiang, Yi Ping Wang, Yang Che Wu, Hsin Ming Chen, Andy Sun

研究成果: 雜誌貢獻文章

37 引文 (Scopus)

摘要

Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.
原文英語
頁(從 - 到)307-312
頁數6
期刊Journal of Oral Pathology and Medicine
46
發行號4
DOIs
出版狀態已發佈 - 四月 1 2017
對外發佈Yes

指紋

Gingivitis
Oral Lichen Planus
Autoantibodies
Antibodies
Bullous Pemphigoid
Serum
Pemphigus
Thyrotropin
Healthy Volunteers
Mucous Membrane
Atrophic Gastritis
Pernicious Anemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

引用此文

Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. / Chang, Julia Yu Fong; Chiang, Chun Pin; Wang, Yi Ping; Wu, Yang Che; Chen, Hsin Ming; Sun, Andy.

於: Journal of Oral Pathology and Medicine, 卷 46, 編號 4, 01.04.2017, p. 307-312.

研究成果: 雜誌貢獻文章

Chang, Julia Yu Fong ; Chiang, Chun Pin ; Wang, Yi Ping ; Wu, Yang Che ; Chen, Hsin Ming ; Sun, Andy. / Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. 於: Journal of Oral Pathology and Medicine. 2017 ; 卷 46, 編號 4. 頁 307-312.
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title = "Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis",
abstract = "Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91{\%}), PV in 40 (8{\%}), and MMP in five (1{\%}) patients. We found that 37.0{\%}, 43.6{\%}, and 42.6{\%} of 500 patients with DG, 39.6{\%}, 46.4{\%}, and 45.1{\%} of 455 EOLP with DG (EOLP/DG) patients, and 18.5{\%}, 27.5{\%}, and 30.3{\%} of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3{\%}, 6.7{\%}, and 9.0{\%} patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4{\%} DG, 77.1{\%} EOLP/DG, and 47.4{\%} EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.",
keywords = "antigastric parietal cell antibody, antithyroglobulin antibody, antithyroid microsomal antibody, desquamative gingivitis, erosive oral lichen planus",
author = "Chang, {Julia Yu Fong} and Chiang, {Chun Pin} and Wang, {Yi Ping} and Wu, {Yang Che} and Chen, {Hsin Ming} and Andy Sun",
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T1 - Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis

AU - Chang, Julia Yu Fong

AU - Chiang, Chun Pin

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Chen, Hsin Ming

AU - Sun, Andy

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.

AB - Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.

KW - antigastric parietal cell antibody

KW - antithyroglobulin antibody

KW - antithyroid microsomal antibody

KW - desquamative gingivitis

KW - erosive oral lichen planus

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