Anticataractogenesis Mechanisms of Curcumin and a Comparison of Its Degradation Products: An in Vitro Study

Jiahn Haur Liao, Yi Shiang Huang, Yu Ching Lin, Fu Yung Huang, Shih Hsiung Wu, Tzu Hua Wu

研究成果: 雜誌貢獻文章

7 引文 斯高帕斯(Scopus)

摘要

Curcumin (Cur) exhibits anticataractogenesis activity. This study aimed to compare the activities of Cur with those of its degradation products in a series of in vitro lens protein turbidity assays. The results show that Cur (200 ) ameliorates selenite-induced crystallin aggregation, and the mean OD value was 0.10 ± 0.02 (p <0.05), which was significantly different from controls (0.15 ± 0.01) after incubating for 3 days. However, Cur did not significantly inhibit calcium-induced proteolysis after incubating for 3 days. Such results were supported by isothermal titration calorimetry observation that Cur binds with selenite but not with calcium. Presence of Cur and the degradation products examined (ferulic acid, cinnamic acid, vanillin, and vanillic acid) indicates significantly protective activities on lens -crystallins after UVC exposure for 3 h. Among the compounds examined, only ferulic acid exhibited a significant inhibitory effect against UVB-induced turbidity with a mean OD of 0.32 ± 0.01 (p <0.05), which was significantly different from controls (0.49 ± 0.02). The previously reported anticataract effects of Cur may stem not only from Cur but also from its degradation products through various cataractogenesis mechanisms in vitro.

原文英語
頁(從 - 到)2080-2086
頁數7
期刊Journal of Agricultural and Food Chemistry
64
發行號10
DOIs
出版狀態已發佈 - 三月 16 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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