Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo

Yeung Leung Cheng, Shih Chun Lee, Shinn Zong Lin, Wen Liang Chang, Yi Lin Chen, Nu Man Tsai, Yao Chi Liu, Ching Tzao, Dah Shyong Yu, Horng Jyh Harn

研究成果: 雜誌貢獻文章

48 引文 斯高帕斯(Scopus)

摘要

Nan-Chai-Hu, the root of Bupleurum scorzonerifolium, is a traditional Chinese herb used in treatment of liver diseases such as hepatitis and cirrhosis. We recently reported that the acetone extract of B. scorzonerifolium (BS-AE) could inhibit proliferation and induce apoptosis in A549 human lung cancer cells. We further examined its anti-proliferative mechanisms and in vivo anticancer effect. Our results showed that BS-AE had the ability to cause cell cycle arrest in G2/M phase, inducing tubulin polymerization, and activating caspase-3 and -9 in A549 cells. BS-AE-induced apoptosis could be blocked by the broad caspase inhibitor z-VAD-fmk in majority. The result of in vivo study showed that BS-AE could suppress growth in A549 subcutaneous xenograft tumors. These results indicate that BS-AE exerts antiproliferative effects on A549 cells in vitro and in vivo, and prompted us to further evaluate and elucidate the chemical composition profile of BS-AE.

原文英語
頁(從 - 到)183-193
頁數11
期刊Cancer Letters
222
發行號2
DOIs
出版狀態已發佈 - 五月 26 2005
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

指紋 深入研究「Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo」主題。共同形成了獨特的指紋。

  • 引用此

    Cheng, Y. L., Lee, S. C., Lin, S. Z., Chang, W. L., Chen, Y. L., Tsai, N. M., Liu, Y. C., Tzao, C., Yu, D. S., & Harn, H. J. (2005). Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Letters, 222(2), 183-193. https://doi.org/10.1016/j.canlet.2004.10.015