Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo

Yeung Leung Cheng, Shih Chun Lee, Shinn Zong Lin, Wen Liang Chang, Yi Lin Chen, Nu Man Tsai, Yao Chi Liu, Ching Tzao, Dah Shyong Yu, Horng Jyh Harn

研究成果: 雜誌貢獻 › 文章

45 引文 (Scopus)

摘要

Nan-Chai-Hu, the root of Bupleurum scorzonerifolium, is a traditional Chinese herb used in treatment of liver diseases such as hepatitis and cirrhosis. We recently reported that the acetone extract of B. scorzonerifolium (BS-AE) could inhibit proliferation and induce apoptosis in A549 human lung cancer cells. We further examined its anti-proliferative mechanisms and in vivo anticancer effect. Our results showed that BS-AE had the ability to cause cell cycle arrest in G2/M phase, inducing tubulin polymerization, and activating caspase-3 and -9 in A549 cells. BS-AE-induced apoptosis could be blocked by the broad caspase inhibitor z-VAD-fmk in majority. The result of in vivo study showed that BS-AE could suppress growth in A549 subcutaneous xenograft tumors. These results indicate that BS-AE exerts antiproliferative effects on A549 cells in vitro and in vivo, and prompted us to further evaluate and elucidate the chemical composition profile of BS-AE.

原文英語
頁（從 - 到）183-193
頁數11
期刊Cancer Letters
卷222
發行號2
DOIs
出版狀態已發佈 - 五月 26 2005
對外發佈Yes

指紋

Bupleurum
Lung Neoplasms
Apoptosis
Caspase Inhibitors
Caspase 9
G2 Phase
Tubulin
Acetone
Cell Cycle Checkpoints
Heterografts
Caspase 3
Polymerization
Cell Division
Hepatitis
Liver Diseases
Fibrosis
Growth
Neoplasms
A549 Cells
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

引用此文

Cheng, Y. L., Lee, S. C., Lin, S. Z., Chang, W. L., Chen, Y. L., Tsai, N. M., ... Harn, H. J. (2005). Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Letters, 222(2), 183-193. https://doi.org/10.1016/j.canlet.2004.10.015

Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. / Cheng, Yeung Leung; Lee, Shih Chun; Lin, Shinn Zong; Chang, Wen Liang; Chen, Yi Lin; Tsai, Nu Man; Liu, Yao Chi; Tzao, Ching; Yu, Dah Shyong; Harn, Horng Jyh.

於: Cancer Letters, 卷 222, 編號 2, 26.05.2005, p. 183-193.

研究成果: 雜誌貢獻 › 文章

Cheng, YL, Lee, SC, Lin, SZ, Chang, WL, Chen, YL, Tsai, NM, Liu, YC, Tzao, C, Yu, DS & Harn, HJ 2005, 'Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo', Cancer Letters, 卷 222, 編號 2, 頁 183-193. https://doi.org/10.1016/j.canlet.2004.10.015
Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM 等. Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. Cancer Letters. 2005 5月 26;222(2):183-193. https://doi.org/10.1016/j.canlet.2004.10.015
Cheng, Yeung Leung ; Lee, Shih Chun ; Lin, Shinn Zong ; Chang, Wen Liang ; Chen, Yi Lin ; Tsai, Nu Man ; Liu, Yao Chi ; Tzao, Ching ; Yu, Dah Shyong ; Harn, Horng Jyh. / Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo. 於: Cancer Letters. 2005 ; 卷 222, 編號 2. 頁 183-193.
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AU - Chang, Wen Liang

AU - Chen, Yi Lin

AU - Tsai, Nu Man

AU - Liu, Yao Chi

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AU - Harn, Horng Jyh

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