Anti-inflammatory effects of Calophyllum inophyllum L. in RAW264.7 cells

Shih Chang Tsai, Yu Hsin Liang, Jo Hua Chiang, Fon Chang Liu, Wen Hsin Lin, Shu Jen Chang, Wei Yu Lin, Chieh Hsi Wu, Jing Ru Weng

研究成果: 雜誌貢獻文章同行評審

32 引文 斯高帕斯(Scopus)

摘要

Calophyllum inophyllum L. has been used as folk medicine in the treatment of ocular burn and it has demonstrated potential to be an anti-inflammatory agent. The aim of this study was to explore the anti-inflammatory activities of an acetone extract of C. inophyllum L. leaves (CIL). The CIL extract was tested on lipopolysaccharide (LPS)-induced RAW 264.7 cells to evaluate the effect of CIL extract on the expression of nitric oxide (NO) and inducible nitric oxide synthase (iNOS). Results showed that the CIL extract markedly suppressed the LPS-induced production of nitric oxide, as well as the expression of iNOS, cyclooxygenase (COX)-2 and nuclear factor-kappaB (NF-κB) in a dose-dependent manner. LPS-induced microRNA (miR)-146a expression was inhibited by CIL extract, while miR-155 and miR-424 expression was not affected as demonstrated using quantitative RT-PCR analysis. Taken together, these observations show that CIL extract has anti-inflammatory effect, which extends the potential application for prevention of inflammatory diseases, and its mechanism may be partially associated with blocking COX-2 and iNOS of RAW 264.7 cells.

原文英語
頁(從 - 到)1096-1102
頁數7
期刊Oncology Reports
28
發行號3
DOIs
出版狀態已發佈 - 9月 2012
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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