Anti-a-enolase is a prognostic marker in postoperative lung cancer patients

Kuan Chung Hsiao, Neng Yao Shih, Pei Yi Chu, Yi Mei Hung, Jia Yi Liao, Shao Wen Chou, Yi Yuan Yang, Gee Chen Chang, Ko Jiunn Liu

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients.

原文英語
頁(從 - 到)35073-35086
頁數14
期刊Oncotarget
6
發行號33
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • 腫瘤科

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