Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis

Shin Chen Hou, Li Wei Chan, Yu Chi Chou, Ching Yuan Su, Xin Chen, Yen Ling Shih, Pei Chun Tsai, C. K.James Shen, Yu Ting Yan

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.

原文英語
頁(從 - 到)2765-2771
頁數7
期刊FEBS Letters
583
發行號17
DOIs
出版狀態已發佈 - 九月 3 2009
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

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