Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats

Te Chao Fang, Wann Chu Huang

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)

摘要

The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P

原文英語
頁(從 - 到)235-242
頁數8
期刊Hypertension
32
發行號2
出版狀態已發佈 - 八月 1998
對外發佈

ASJC Scopus subject areas

  • 內科學

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