摘要
The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P
原文 | 英語 |
---|---|
頁(從 - 到) | 235-242 |
頁數 | 8 |
期刊 | Hypertension |
卷 | 32 |
發行號 | 2 |
出版狀態 | 已發佈 - 8月 1998 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 內科學