Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats

Te Chao Fang; Wann Chu Huang

Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats

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摘要

The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P

原文	英語
頁（從 - 到）	235-242
頁數	8
期刊	Hypertension
卷	32
發行號	2
出版狀態	已發佈 - 8月 1998
對外發佈	是

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AB - The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P

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Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats

摘要

ASJC Scopus subject areas

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引用此