Angiotensin II and angiotensin II receptor blocker modulate the arrhythmogenic activity of pulmonary veins

Yi Jen Chen, Yao Chang Chen, Ching Tai Tai, Hung I. Yeh, Cheng I. Lin, Shih Ann Chen

研究成果: 雜誌貢獻文章

66 引文 斯高帕斯(Scopus)

摘要

1. Angiotensin II receptor blockers (AIIRBs) have been shown to prevent atrial fibrillation. The pulmonary veins (PVs) are the most important focus for the generation of atrial fibrillation. The aim of this study was to evaluate whether angiotensin II or AIIRB may change the arrhythmogenic activity of the PVs. 2. Conventional microelectrodes and whole-cell patch clamps were used to investigate the action potentials (APs) and ionic currents in isolated rabbit PV tissue and single cardiomyocytes before and after administering angiotensin II or losartan (AIIRB). 3. In the tissue preparations, angiotensin II induced delayed after-depolarizations (1, 10, and 100 nM) and accelerated the automatic rhythm (10 and 100 nM). Angiotensin II (100 nM) prolonged the AP duration and increased the contractile force (10 and 100 nM). Losartan (1 and 10 μM) inhibited the automatic rhythm. Losartan (10 μM) prolonged the AP duration and reduced the contractile force (1 and 10 μM). 4. Angiotensin II reduced the transient outward potassium current (I to) but increased the L-type calcium, delayed rectifier potassium (I K), transient inward (I ti), pacemaker, and Na +-Ca 2+ exchanger (NCX) currents in the PV cardiomyocytes. Losartan decreased the I to, I K, I ti, and NCX currents. 5. In conclusion, angiotensin II and AIIRB modulate the PV electrical activity, which may play a role in the pathophysiology of atrial fibrillation.

原文英語
頁(從 - 到)12-22
頁數11
期刊British Journal of Pharmacology
147
發行號1
DOIs
出版狀態已發佈 - 一月 2006

ASJC Scopus subject areas

  • Pharmacology

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