Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease

Han Cheng Wang, Che Chen Lin, Chi Ieong Lau, Anna Chang, Chia Hung Kao

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.
原文英語
頁(從 - 到)593-596
頁數4
期刊Movement Disorders
30
發行號4
DOIs
出版狀態已發佈 - 四月 1 2015

指紋

Bacterial Pneumonia
Angiotensin-Converting Enzyme Inhibitors
Parkinson Disease
Pneumonia
Angiotensin Receptor Antagonists
Hypertension
Risk Reduction Behavior
Cohort Studies
Observation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

引用此文

Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease. / Wang, Han Cheng; Lin, Che Chen; Lau, Chi Ieong; Chang, Anna; Kao, Chia Hung.

於: Movement Disorders, 卷 30, 編號 4, 01.04.2015, p. 593-596.

研究成果: 雜誌貢獻文章

Wang, Han Cheng ; Lin, Che Chen ; Lau, Chi Ieong ; Chang, Anna ; Kao, Chia Hung. / Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease. 於: Movement Disorders. 2015 ; 卷 30, 編號 4. 頁 593-596.
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AU - Lin, Che Chen

AU - Lau, Chi Ieong

AU - Chang, Anna

AU - Kao, Chia Hung

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N2 - Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.

AB - Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.

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KW - Parkinson's disease

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