Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease

Fan Chi Chang, Tai Shuan Lai, Chih Kang Chiang, Yung Ming Chen, Ming Shiou Wu, Tzong Shinn Chu, Kwan Dun Wu, Shuei Liong Lin

研究成果: 雜誌貢獻文章

26 引文 斯高帕斯(Scopus)

摘要

Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria (300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211-0.386, P

原文英語
文章編號e54668
期刊PLoS One
8
發行號3
DOIs
出版狀態已發佈 - 三月 1 2013
對外發佈Yes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • 引用此

    Chang, F. C., Lai, T. S., Chiang, C. K., Chen, Y. M., Wu, M. S., Chu, T. S., Wu, K. D., & Lin, S. L. (2013). Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease. PLoS One, 8(3), [e54668]. https://doi.org/10.1371/journal.pone.0054668