Angiogenesis is not mediated by prostate cancer neuropeptides

J. E. Busby, S. J. Shih, J. C. Yang, H. J. Kung, C. P. Evans

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Once metastatic, prostate cancer (CaP) treatment options are limited to androgen withdrawal. In this environment, the cells often develop an androgen independent state resulting in patient demise. It has been shown that during this transition, CaP cells transdifferentiate to neuroendocrine cells, which produce neuropeptides. These neuropeptides have a mitogenic effect on surrounding CaP cells. Previous observations suggest that endothelial cells may show a similar mitogenic response to neuropeptides, implicating angiogenesis in the progression of CaP. We stimulated human umbilical endothelial cells (HUVECs) with the neuropeptides bombesin and neurotensin and measured proliferation, migration, cell tube formation, and tyrosine kinase activation. In our studies, neurotensin and bombesin did not stimulate HUVEC proliferation, migration, nor tube formation. Although HUVECs express the non-receptor tyrosine kinases Fak, Src, and Etk which mediate neuropeptide signaling in CaP, they are not activated by neuropeptides in HUVECs.
原文英語
頁(從 - 到)289-293
頁數5
期刊Angiogenesis
6
發行號4
DOIs
出版狀態已發佈 - 十二月 1 2003
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 病理學與法醫學
  • 臨床生物化學
  • 聚合物和塑料

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