Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Ming Shian Lee, Shih Wei Wang, Guei Jane Wang, Ka Lai Pang, Ching Kuo Lee, Yueh Hsiung Kuo, Hyo Jung Cha, Ruo Kai Lin, Tzong Huei Lee

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

Seven new polyketides, phomaketides A-E (1-5) and pseurotins A3 (6) and G (7), along with the known compounds FR-111142, pseurotins A, A1, A2, D, and F2, 14-norpseurotin A, α-carbonylcarbene, tyrosol, cyclo(-l-Pro-l-Leu), and cyclo(-l-Pro-l-Phe), were purified from the fermentation broth and mycelium of the endophytic fungal strain Phoma sp. NTOU4195 isolated from the marine red alga Pterocladiella capillacea. The structures were established through interpretation of spectroscopic data. The antiangiogenic and anti-inflammatory effects of 1-7 and related analogues were evaluated using human endothelial progenitor cells (EPCs) and lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, respectively. Of the compounds tested, compound 1 exhibited the most potent antiangiogenic activity by suppressing the tube formation of EPCs with an IC50 of 8.1 μM, and compound 3 showed the most selective inhibitory activity of LPS-induced NO production in RAW264.7 macrophages with an IC50 value of 8.8 μM.

原文英語
頁(從 - 到)2983-2990
頁數8
期刊Journal of Natural Products
79
發行號12
DOIs
出版狀態已發佈 - 十二月 23 2016

    指紋

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

引用此

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K., & Lee, T. H. (2016). Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195. Journal of Natural Products, 79(12), 2983-2990. https://doi.org/10.1021/acs.jnatprod.6b00407