Androgen receptor regulates SRC expression through microRNA-203

Man Kit Siu, Wei Yu Chen, Hong Yuan Tsai, Hsiu Lien Yeh, Juan Juan Yin, Shih Yang Liu, Yen-Nien Liu

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

The SRC kinase has pivotal roles in multiple developmental processes and in tumor progression. An inverse relationship has been observed between androgen receptor (AR) activity and SRC signaling in advanced prostate cancer (PCa); however, the modulation of AR/SRC crosstalk that leads to metastatic PCa is unclear. Here, we showed that patients with high SRC levels displayed correspondingly low canonical AR gene signatures. Our results demonstrated that activated AR induced miR-203 and reduced SRC levels in PCa model systems. miR-203 directly binds to the 3' UTR of SRC and regulates the stability of SRC mRNA upon AR activation. Moreover, we found that progressive PCa cell migration and growth were associated with a decrease in AR-regulated miR-203 and an increase in SRC. Relationships among AR, miR-203, and SRC were also confirmed in clinical datasets and specimens. We suggest that the induction of SRC results in increased PCa metastasis that is linked to the dysregulation of the AR signaling pathway through the inactivation of miR-203.
原文英語
頁(從 - 到)25726-25741
頁數16
期刊Oncotarget
7
發行號18
DOIs
出版狀態已發佈 - 五月 1 2016

ASJC Scopus subject areas

  • 腫瘤科

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