Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu, Jin Ding Huang, Shi Wei Huang, Tzyh Chyuan Hour, Yung Kai Huang, Yu Mei Hsueh, Hung Yi Chiou, Te Chang Lee, Kun Yan Jan, Chien Jen Chen, Yeong Shiau Pu

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (
原文英語
頁(從 - 到)261-269
頁數9
期刊Journal of Biomedical Science
15
發行號2
DOIs
出版狀態已發佈 - 三月 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Liu, C. H., Huang, J. D., Huang, S. W., Hour, T. C., Huang, Y. K., Hsueh, Y. M., Chiou, H. Y., Lee, T. C., Jan, K. Y., Chen, C. J., & Pu, Y. S. (2008). Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. Journal of Biomedical Science, 15(2), 261-269. https://doi.org/10.1007/s11373-007-9215-x