Androgen modulates cardiac fibrosis contributing to gender differences on heart failure

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Chronic heart failure (HF) is a major health problem throughout the world. Gender has significant effects on the pathophysiology of HF. Low levels of free testosterone are independently associated with increased chronic HF symptoms and mortality. Cardiac fibrosis plays a pivotal role in structural remodeling in HF. Transforming growth factor (TGF)-β, angiotensin II and oxidative stress contribute to the activity/extent of cardiac fibrosis. Androgen deficiency can up-regulate TGF-β expression under angiotensin II stimulation in vivo. In this review, we summarized the potential mechanisms accounting for the effects of androgen on cardiac fibrosis through regulating fibrocytes activity under TGF, which can explain wound healing and cardiac fibrosis in male with acute myocardial injury and chronic HF.
原文英語
頁(從 - 到)22-27
頁數6
期刊Aging Male
16
發行號1
DOIs
出版狀態已發佈 - 三月 2013

ASJC Scopus subject areas

  • Geriatrics and Gerontology

指紋 深入研究「Androgen modulates cardiac fibrosis contributing to gender differences on heart failure」主題。共同形成了獨特的指紋。

引用此