Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery

Kuo Yuan Hwa, Vincent H.S. Chang, Yao Yi Cheng, Yue Da Wang, Pey Shynan Jan, Boopathi Subramani, Min Ju Wu, Bo Kai Wang

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Traditional drug delivery systems, using invasive, transdermal, and oral routes, are limited by various factors, such as the digestive system environment, skin protection, and sensory nerve stimulation. To improve the drug delivery system, we fabricated a polysaccharide-based, dissolvable microneedle-based array, which combines the advantages of both invasive and transdermal delivery systems, and promises to be an innovative solution for minimally invasive drug delivery. In this study, we designed a reusable aluminum mold that greatly improved the efficiency and convenience of microneedle fabrication. Physical characterization of the polysaccharides, individual or mixed at different ratios, was performed to identify a suitable molecule to fabricate the dissolvable microneedle. We used a vacuum deposition-based micro-molding method at low temperature to fabricate the model. Using a series of checkpoints from material into product, a systematic feedback mechanism was built into the “all-in-one” fabrication step, which helped to improve production yields. The physical properties of the fabricated microneedle were assessed. The cytotoxicity analysis and animal testing of the microneedle demonstrated the safety and compatibility of the microneedle, and the successful penetration and effective release of a model protein.
原文英語
文章編號84
期刊Biomedical Microdevices
19
發行號4
DOIs
出版狀態已發佈 - 十二月 1 2017

指紋

Drug Delivery Systems
Polysaccharides
Digestive system
Fabrication
Vacuum deposition
Digestive System
Cytotoxicity
Vacuum
Aluminum
Drug delivery
Molding
Skin
Animals
Fungi
Physical properties
Proteins
Feedback
Safety
Molecules
Temperature

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Biology

引用此文

Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery. / Hwa, Kuo Yuan; Chang, Vincent H.S.; Cheng, Yao Yi; Wang, Yue Da; Jan, Pey Shynan; Subramani, Boopathi; Wu, Min Ju; Wang, Bo Kai.

於: Biomedical Microdevices, 卷 19, 編號 4, 84, 01.12.2017.

研究成果: 雜誌貢獻文章

Hwa, Kuo Yuan ; Chang, Vincent H.S. ; Cheng, Yao Yi ; Wang, Yue Da ; Jan, Pey Shynan ; Subramani, Boopathi ; Wu, Min Ju ; Wang, Bo Kai. / Analyzing polymeric matrix for fabrication of a biodegradable microneedle array to enhance transdermal delivery. 於: Biomedical Microdevices. 2017 ; 卷 19, 編號 4.
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