An unusual role of folate in the self-assembly of heparin-folate conjugates into nanoparticles

Jianquan Wang, Daoshuang Ma, Qian Lu, Shaoxiong Wu, Gee Young Lee, Lucas A. Lane, Bin Li, Li Quan, Yiqing Wang, Shuming Nie

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Tumor targeting agents including antibodies, peptides, and small molecules, are often used to improve the delivery efficiency of nanoparticles. Despite numerous studies investigating the abilities of targeting agents to increase the accumulation of nanosized therapeutics within diseased tissues, little attention has been focused on how these ligands can affect the self-assembly of the nanoparticle's modified polymer constituents upon chemical conjugation. Here we present an actively tumor targeted nanoparticle constructed via the self-assembly of a folate modified heparin. Folate conjugation unexpectedly allowed the self-assembly of heparin, where a majority of the folate molecules (>80%) resided inside the core of the nanoparticle. The folate-heparin nanoparticles could also physically encapsulate lipophilic fluorescent dyes, enabling the use of the constructs as activatable fluorescent probes for targeted in vivo tumor imaging.
原文英語
頁(從 - 到)15185-15190
頁數6
期刊Nanoscale
7
發行號37
DOIs
出版狀態已發佈 - 10月 7 2015
對外發佈

ASJC Scopus subject areas

  • 材料科學(全部)

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