An investigation of the relationships between postoperative pain trajectories and outcomes after surgery for colorectal cancer

Wen Kuei Chang, Ying Hsuan Tai, Shih Pin Lin, Hsiang Ling Wu, Mei Yung Tsou, Kuang Yi Chang

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background: Although animal studies have shown that pain can suppress host immunity and promote tumor metastasis, few clinical studies have evaluated the association between acute pain and long-term outcomes after cancer surgery. Methods: Patients undergoing colorectal cancer resection at a medical center between November 2010 and December 2014 were collected. Pain intensity was recorded using a numeric rating scale at 12, 24, 36, 48, 72, 96, and 120 hours postoperatively. Group-based modeling of longitudinal pain scores was used to categorize pain trajectories. Recurrence-free survival and overall survival were analyzed using Cox proportional hazards models. Results: A total of 2401 patients with 13 931 pain score observations were analyzed. The trajectory model identified three groupings of inpatient postsurgical pain, including 70.3% with mild pain dropping to low (group 1), 20.0% with moderate/severe pain dropping to mild (group 2), and 9.7% with moderate pain rebounding to severe (group 3). Univariate models showed that pain trajectories were significantly associated with recurrence-free survival (group 2 vs 1: hazard ratio [HR], 1.23; 95% CI, 1.02-1.47 and group 3 vs 1: HR, 1.63; 95% CI, 1.30-2.04) and overall survival (group 2 vs 1: HR, 1.36; 95% CI, 1.05-1.77 and group 3 vs 1: HR, 1.81; 95% CI, 1.31-2.51). However, the associations disappeared after adjusting for other significant risk factors. Conclusion: Abnormal pain resolution identified by pain trajectory analysis and resulting from complex interactions among disease progression, surgery, and analgesia may be considered as an indicator of an inferior prognosis following colorectal cancer resection.

原文英語
頁(從 - 到)865-871
頁數7
期刊Journal of the Chinese Medical Association
82
發行號11
DOIs
出版狀態已發佈 - 一月 1 2019

ASJC Scopus subject areas

  • 醫藥 (全部)

指紋

深入研究「An investigation of the relationships between postoperative pain trajectories and outcomes after surgery for colorectal cancer」主題。共同形成了獨特的指紋。

引用此