An investigation of the effect of patient-controlled analgesia on long-term quality of life after major surgery: A prospective cohort study

Ying Hsuan Tai, Hsiang Ling Wu, Shih Pin Lin, Mei Yung Tsou, Kuang Yi Chang

研究成果: 雜誌貢獻回顧型文獻

5 引文 斯高帕斯(Scopus)

摘要

Background: Chronic pain is a common postoperative complication in patients undergoing major surgery and may significantly affect their quality of life (QOL). Whether patient-controlled analgesia (PCA) can reduce the risk of chronic postsurgical pain and promote long-term QOL is still unclear. Methods: In this prospective cohort study, we followed up patients undergoing major surgery, recorded changes in their postoperative QOL over time using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire and chronic pain events, evaluated the long-term effects of distinct PCA techniques (intravenous, epidural, or none) on their QOL and risk of chronic pain, and explored relevant predictors. The patients' QOL and chronic pain events were collected preoperatively, 3, 6, and 12 months after surgery. Generalized linear mixed models were used to control for individual heterogeneity and adjust for potential confounding factors. Results: We included 328 patients undergoing major surgery from September 22, 2015, to December 31, 2016, in this study. Multivariate regression models showed that patients using intravenous PCA had a better QOL in physical health (adjusted coefficient 3.7, 95% CI, 0.5-8.0) compared with those receiving non-PCA treatments. Distinct PCA techniques did not significantly affect QOL in psychological, social relationship, or environmental domains of the WHOQOL-BREF scale or the risk of chronic postsurgical pain. Conclusion: Patients using intravenous PCA had a better QOL in physical health over time after major surgery, which may have been due to factors other than pain-relieving effects.

原文英語
頁(從 - 到)194-201
頁數8
期刊Journal of the Chinese Medical Association
83
發行號2
DOIs
出版狀態已發佈 - 一月 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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