An integrated system of RBCs sorting and Brownian motion bio-sensing technique

Yu Jui Fan, Ching Jiun Lee, Jen Hao Hsu, Yi Hsing Liu, Szu I. Yeh, Horn Jiunn Sheen, Shiming Lin, Jing Fa Tsai

研究成果: 書貢獻/報告類型會議貢獻

摘要

A clinical sorting chip integrated with new protein sensing technique has been developed in this work. Antibody-coated nanobeads reacted with antigen was separated from blood plasma based on dielectrophoresis (DEP) forces. MEMS fabrication process was used to produce the bio-chip and only two photo masks were required in the experiment. By using oxygen-plasma direct bonding method, the assembly of an electrode chip and the microchannels will form a set of RBCs and nanobeads separating chip. The original concentration of antigen can be rapidly estimated by nanobeads' Brownian motion measurement in varies of the viscous solutions. During the antibody-antigen reacting, the mean value of the beads diameter increased so that the Brownian velocity decreased with increasing time. The Brownian motion of nanobeads was observed and measured by micro-particle tracking velocimetry (μ-PTV).
原文英語
主出版物標題2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
頁面487-491
頁數5
DOIs
出版狀態已發佈 - 2010
對外發佈Yes
事件5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 - Xiamen, 中国
持續時間: 一月 20 2010一月 23 2010

會議

會議5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
國家中国
城市Xiamen
期間1/20/101/23/10

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • 引用此

    Fan, Y. J., Lee, C. J., Hsu, J. H., Liu, Y. H., Yeh, S. I., Sheen, H. J., Lin, S., & Tsai, J. F. (2010). An integrated system of RBCs sorting and Brownian motion bio-sensing technique. 於 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 (頁 487-491). [5592441] https://doi.org/10.1109/NEMS.2010.5592441