An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model

Syamsiah Syam, Chun Wei Chang, Wen Chien Lan, Keng Liang Ou, Bai Hung Huang, Yu Yeong Lin, Takashi Saito, Hsin Yu Tsai, Yen Chun Chuo, Tzu Sen Yang, Chung Ming Liu, Ping Jen Hou

研究成果: 雜誌貢獻文章同行評審

摘要

This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.

原文英語
文章編號5271
期刊Applied Sciences (Switzerland)
11
發行號11
DOIs
出版狀態已發佈 - 六月 1 2021

ASJC Scopus subject areas

  • 材料科學(全部)
  • 儀器
  • 工程 (全部)
  • 製程化學與技術
  • 電腦科學應用
  • 流體流動和轉移過程

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