An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer

Sheng En Chou, Chun Ying Huang, Shyr Ming Sheen-Chen, Yueh Wei Liu, Ching Hua Tsai, Yu Hung Lin, Chao Cheng Huang, Rei Ping Tang

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background: The benefit of tissue microarray (TMA) is its capability to analyse large numbers of tissue samples in a uniform fashion. This study was designed to evaluate the capability of TMA for analyzing the status of death-associated protein kinase 1 (DAPK1) in breast cancer patient and to explore its potential in the management of breast cancer. Patients and Methods: Over a 60-month period, tissue specimens of 99 patients with primary invasive breast cancer were selected. Tissue microarray (TMA) was applied to detect the DAPK1 expression. The data for the other clinicopathologic variables, including age, histological grading, estrogen receptor status and TNM staging were also recorded. Results: Tumor in 11 patients (11.1%) scored 1 for DAPK1 expression, 55 patients (55.6%) scored 2 and 33 (33.3%) scored 3. We found no obvious link between DAPK1 expression and age, histologic grading, primary tumor staging, lymph node status, estrogen receptor and TNM stage. TNM staging was found to be significantly linked to the overall five-year survival rate through multivariate analysis. Conclusion: DAPK1 expression did not show any meaningful value in predicting outcome for patients with breast cancer.

原文英語
頁(從 - 到)3633-3636
頁數4
期刊Anticancer Research
31
發行號10
出版狀態已發佈 - 十月 1 2011
對外發佈Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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