An evaluation of focal adhesion kinase in breast cancer by tissue microarrays

Shyr Ming Sheen-Chen, Chun Ying Huang, Yi Chia Chan, Ching Hua Tsai, Shun Yu Chi, Shih Chung Wu, Chao Cheng Huang, Rei Ping Tang, Hock Liew Eng, Sheung Fat Ko, Yi Wei Lee, Jiun Lung Liang, Eng Yen Huang, Hui Chun Chen, Kung Ming Rau

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Background: Many studies have shown that focal adhesion kinase (FAK) is a positive regulator of tumor progression and invasion. However, there is still very limited information about the role of FAK in breast cancer. Tissue microarrays (TMA) can analyze thousands of tissue samples in a parallel fashion with minimal damage to the origin block. This study was designed with the application of TMA to analyze the FAK status in breast cancer. Patients and Methods: Archival tissue specimens from 98 patients with primary invasive breast cancer were selected and FAK expression was analyzed by immunohistochemical staining with TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. Results: There were four patients (4.0%) with grade 1 expression in FAK, 41 patients (41.8%) with grade 2 expression in FAK and 53 patients (54.2%) with grade 3 expression in FAK. There was no significant relationship between FAK expression and age, estrogen receptor status, histological grading, primary tumor staging, lymph node status and TNM stage. By multivariate analysis, the TNM stage was found to be significantly related to the overall five-year survival rate (p<0.00001). Conclusion: Immunohistochemical staining with TMA is a convenient and feasible method. Unfortunately, our preliminary results fail to show meaningful prognostic value of FAK in breast cancer. A larger prospective study is warranted for further evaluation.

原文英語
頁(從 - 到)1169-1174
頁數6
期刊Anticancer Research
33
發行號3
出版狀態已發佈 - 3月 1 2013
對外發佈

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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